Pharm Ingredients
Hydroxypinacolone Retinoate HPR Powder
Hydroxypinacolone Retinoate HPR Powder Supplier
Hydroxypinacolone retinoate (HPR) is a type of vitamin A and a new generation of retinoic acid ester, formed by the esterification of retinoic acid and the small molecule pinacolol. As a third-generation vitamin A derivative, granactive retinoid is gentler and more effective, offering multiple benefits such as anti-aging, acne prevention, skin whitening and fading dark spots, and regulating epidermal metabolism. It is widely used in cosmetics, pharmaceuticals, and personal care products.
Kintainutri® produces 10% oil-soluble and high-purity 99% HPR hydroxypinazone retinate.
Custom orders are welcome!
| Product Name | Hydroxypinacolone Retinoate HPR Powder | |
|---|---|---|
| Appearance | Yellow crystalline powder | Yellow liquid |
| Specification | 99% HPR | 10% HPR |
| Solubility | Slightly soluble in ethanol, soluble in vegetable oils and fats, insoluble in water. | Oil-soluble |
| Storage | Store in a cool, dark place in a sealed container. | |
Hydroxypinacolone Retinoate HPR Powder Advantages
Hydroxypinazone retinate HPR is a third-generation vitamin A derivative, an ester based on retinoic acid. In recent years, driven by both consumption upgrades and increased demand, HPR has gained significant market favor. Its core advantages include:
1.High efficacy:
Unlike other retinoic acid derivatives, HPR retains the functional groups of retinoic acid completely. It does not need to undergo hydrolysis and transformation in the skin and can directly bind to retinoic acid receptors to exert its effects, significantly increasing the production of procollagen and resulting in extremely high efficacy.
2.Mild and safe (low irritation):
Granactive retinoid is extremely low in irritation because it does not require conversion and does not induce overexpression of inflammatory factors such as IL-1. At the same concentration, its cytotoxicity is lower than that of retinol, retinaldehyde, and retinyl palmitate, and it has no phototoxicity, requiring no complex tolerance-building process during use.
3.Wide range of applications:
With its comprehensive advantages such as being mild and non-irritating, having direct effects, high stability, and strong activity, hydroxypinacolone retinoate powder, as a third-generation vitamin A derivative, has been widely used in many fields such as anti-aging cosmetics and anti-acne drugs.
Retinol vs Retinal vs Granactive Retinoid
| Product Name | Retinol | Retinal/Retinaldehyde | Hydroxypinacolone Retinoate/HPR |
|---|---|---|---|
Ingredient Type |
1st Gen Vitamin A Derivative (Alcohol) | 1st Gen Vitamin A Derivative (Aldehyde) | Synthetic Vitamin A Derivative |
Mechanism of Action |
2-step conversion: Retinol → Retinal → Retinoic Acid | 1-step conversion: Retinal → Retinoic Acid | No conversion needed, directly binds to retinoic acid receptors |
Onset Speed |
Slower (requires enzyme conversion) | Faster (only 1-step conversion) | Fast (direct action) |
Irritancy |
High irritancy, requires long-term tolerance building | Irritancy usually higher than retinol, requires careful tolerance | Extremely low, much lower than retinol/retinal, very low cytotoxicity even at 10x concentration, no tolerance needed |
Stability |
Poor, sensitive to light/heat/oxygen, prone to oxidative inactivation | Better stability than retinol | High stability |
Dermal Absorbability |
Moderate, high molecular weight, requires conversion to work | Moderate, fewer conversion steps, faster onset | Excellent, low molecular weight, easier dermal absorption after structural modification, direct effect |
What are the Skin Benefits of Hydroxypinacolone Retinoate HPR Powder?
Hydroxypinacolone Retinoate for Anti-aging and wrinkle reduction
As a new generation of retinyl ester, HPR can directly bind to retinoic acid receptors, effectively stimulate skin cell renewal and significantly promote the synthesis of type I collagen in human skin fibroblasts, thereby improving problems such as wrinkles and loss of elasticity caused by photoaging.
Clinical studies (especially in Asian populations or those with sensitive skin who have lower tolerance) have shown that multi-effect anti-aging complexes containing Hydroxypinacolone Retinoate HPR can significantly reduce facial wrinkles (such as periorbital wrinkles, forehead wrinkles, nasolabial folds, and neck wrinkles), improve skin elasticity and firmness, enhance barrier function (reduce transepidermal water loss (TEWL), and improve pigmentation; while providing excellent skin tolerance while ensuring a powerful anti-photoaging effect.
In summary, clinical studies have confirmed that HPR can act directly on the skin, making it an ideal choice for creating safe, effective, anti-aging, and wrinkle-reducing high-end skincare ingredients.
Image by https://www.mdpi.com/1999-4923/15/3/731.
Hydroxypinacolone Retinoate for Whitening and Spot Removal
HPR possesses powerful antioxidant capabilities, helping skin maintain a healthy state and improve pigmentation. It also accelerates melanin excretion and inhibits its production, thus exerting a whitening effect. Furthermore, it promotes cell differentiation and renewal, improves skin roughness, inhibits tyrosinase activity, fades age spots and blemishes, and protects elastic fibers by inhibiting the enhancement of MMP activity caused by ultraviolet radiation. It is a highly efficient and multifunctional cosmetic ingredient for developing whitening and photoaging protection.
Hydroxypinacolone Retinoate for Promoting Keratin Metabolism
Studies have shown that HPR not only significantly inhibits IL-6 expression, delivering anti-inflammatory and soothing effects, but also accelerates keratin metabolism, promotes normal keratin differentiation, and catalyzes the synthesis of intercellular lipids, thereby effectively shrinking pores, improving roughness, and making the skin smooth and even.
More importantly, granactive retinoid can directly disrupt the cell walls of Propionibacterium acnes, exhibiting excellent anti-acne effects. This multi-target mechanism makes our hydroxypinacolone retinoate powder an ideal choice for adjuvant treatment of acne, acne removal, and repair in functional skincare products, helping you create more efficient, gentler, and more competitive skincare products.
What is Hydroxypinacolone Retinoate HPR Powder Used For?
HPR Hydroxypinacolone Retinoate Powder is a versatile cosmetic ingredient that can be flexibly applied to various skincare products, such as hydroxypinacolone retinoate serum, hydroxypinacolone retinoate cream, hydroxypinacolone retinoate eye cream, retinoid granactive emulsion.
It helps improve skin tone, brighten complexion, combat aging, reduce wrinkles and dark spots, and enhance skin firmness. Choose Kintainutri®'s hydroxypinacolone retinoate powder to inject multi-dimensional anti-aging energy into your product line and meet consumer demand for highly effective, gentle, and all-around skincare products.
It helps improve skin tone, brighten complexion, combat aging, reduce wrinkles and dark spots, and enhance skin firmness. Choose Kintainutri®'s hydroxypinacolone retinoate powder to inject multi-dimensional anti-aging energy into your product line and meet consumer demand for highly effective, gentle, and all-around skincare products.
Is Hydroxypinacolone Retinoate HPR Powder Safe？
Studies have shown that hydroxypinazone retinate HPR powder, at the same concentration, exhibits stronger gene transcriptional activity than retinol, retinaldehyde, and retinyl palmitate; even at 10 times the concentration, its cytotoxicity remains lower. At the highest dose, HPR's effect on promoting procollagen synthesis is even stronger than trans-retinoic acid, but the induced inflammatory response (marked by IL-1α) does not exceed that of retinoic acid.
In summary, granactive retinoid maintains potent anti-aging effects while exhibiting lower cytotoxicity and milder skin inflammation, making it a safer and less invasive option than retinoic acid, with fewer skin side effects.
Kintainutri® provides cosmetic-grade HPR powder (10% and 99% purity) to customers worldwide. Please contact us if needed.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
About Us
